Senior Scientist (Small Molecule Pre-Formulation, Advanced Drug Delivery)
Introduction to the group
Pharmaceutical Sciences is a department within AstraZeneca Biopharmaceuticals R&D with a mission to transform molecules into investigational medicines, meeting the unmet needs of future patients. Advanced Drug Delivery is a department within Pharmaceutical Sciences. Our portfolio of projects spans traditional small molecules, peptides, oligonucleotides to RNA-based therapeutics across AstraZeneca's therapy areas and our mission is to transform diverse modalities into investigational medicines.
Accountabilities
We are looking for a highly motivated and experienced individual to join the dynamic Advanced Drug Delivery group, supporting the small molecule projects in AstraZeneca pipeline. Main responsibilities for this role include:
Developing formulations, analytical methods, and delivery systems with a focus on small molecules
Serving as a function representative and providing pharmaceutical expertise to global project teams
Planning and conducting experiments with minimum supervision; Generating, evaluating, and reporting data clearly and reliably; Providing data interpretation and making recommendations to project teams and other stakeholders.
Being actively involved with novel formulation development and innovative technology evaluation.
Working as a member of cross-functional pharmaceutical science and CMC project teams, in close collaboration with other formulators, analytical chemists, chemists and biologists at AstraZeneca
Presenting data at internal AstraZeneca meetings and occasionally at external meetings
Education & Experience Requirements
PhD degree in Pharmaceutical Sciences, Material Sciences, Biomedical Engineering or related scientific fields with 2+ years post-graduation experience in pharmaceutical and/or biotechnology environment -OR- MS degree in Pharmaceutical Sciences, Material Sciences, Biomedical Engineering or related scientific fields with 10+ years industry experience in pharmaceutical and/or biotechnology environment.
Essential Skills/Experience
Demonstrated ability in designing and optimizing formulations of poorly soluble compounds for preclinical studies including PROTACs
Knowledge and hands-on experience of enabling formulation technologies including but not limited to amorphous solid dispersion, lipid based formulation and nanoparticles
Hands on experience with analytical instruments for the characterization of formulation and drug products (e.g., HPLC, LC/MS, SFC, DLS, DSC/TGA, XRPD, dissolution.)
Strong analytical, problem solving skills
Track record of scientific excellence in terms of scientific publications, patents, and/or conference presentations
Excellent oral and written communication skills
Ability to effectively lead scientific/project activities
Desirable Skills/Experience
Willingness to acquire new skills or technologies
Work independently and collaboratively in team settings
Modeling and simulation predictions for human oral absorption of drug products
Broad knowledge and understanding of drug discovery and drug development
Understanding of principals and applications of GLS/GLP/GMP
When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.
At AstraZeneca, you will be part of a community of highly qualified and motivated scientists. Our environment is both supportive and challenging, fostering continuous knowledge sharing and constructive critique. We are dedicated to improving patient outcomes through innovative science and collaboration across all therapy areas.
Ready to make a difference? Apply now to join our team!
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.
