Job Description:
Job title: Upstream Manager Scientist
Location: Swiftwater, PA
About the Job
We deliver 4.3 billion healthcare solutions to people every year, thanks to the flawless planning and meticulous eye for detail of our Manufacturing & Supply teams. With your talent and ambition, we can do even more to protect people from infectious diseases and bring hope to patients and their families.
The Upstream Development Group, as a part of the Manufacturing Technology Department, has responsibilities to support the development and continuous improvement of bioprocesses for manufacturing of Influenza, Meningitis, COVID, and other vaccines. It encompasses the development of seeds, production processes (Batch and Fed-Batch), evaluation, and improvements of process parameters.
Primary responsibility will be to work as a part of the working virus bank (WVB) generation group. WVB is a recombinant baculovirus seed for manufacturing drug substances for Influenza & COVID vaccines.
We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people's lives. We're also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?
Main Responsibilities:
- Maintenance of insect cells in suspension culture at different scales (shake flasks, waves, small and pilot size bioreactors)
- Transfection of insect cells, baculovirus plaque purification, infection & scale-up of baculovirus stocks
- Sampling cell culture and preparation of samples for analytical testing
- Performing standard molecular biology tasks such as baculovirus DNA purification, PCR, restriction endonucleases digest, DNA agarose gel electrophoresis
- Performing analysis of recombinant protein expression by Western blot, SDS-PAGE, FACs and single radial immunodiffusion techniques (SRID)
- Responsible for completing paperwork for each task
- Maintenance of the labs and ordering of supplies
- Communicate with co-workers and present data on a regular basis at the group and department meetings
- Flexible in time management
- Complies with all company policies and standard
How:
- Behaves according to company values and competencies.
- Influences internally; forward thinking with an attitude of collaboration, optimization, efficiency, continuous improvement.
- Proactively anticipates and effectively communicates successes, constraints, conflicts, solutions and actions for resolution.
- Proactively resolves conflicts, removes roadblocks to execution within sphere of influence; escalates to functional management when appropriate. \
- Fosters relationships with partners, experts from other functions and customers in order to achieve technical objectives.
About You
Basic Qualifications
- Bachelor or Master in biology, cell biology, molecular biology, biochemistry, chemistry or related field.
- Experience in cell and molecular biology techniques and, procedures, and aseptic techniques.
- Ability to utilize Microsoft Excel, PowerPoint and Word to perform tasks
- Ability to plan and conduct laboratory experiments, evaluate, and interpret data.
- Ability to work with minimum supervision.
- Willing to work changing schedules and hours as needed
- Able to work effectively in a collaborative team
- Strong verbal and written communication skills.
- Detail-oriented and ability to prioritize assignments.
- Fluent in both written and spoken English
Preferred Qualifications
- >1 year of industry experience in cell and molecular biology techniques and, procedures, and aseptic techniques.
- Experience in cell culture procedures and associated aseptic techniques
- Experience in molecular biology procedures
Why Choose Us?
- Bring the miracles of science to life alongside a supportive, future-focused team.
- Discover endless opportunities to grow your talent and drive your career, whether it's through a promotion or lateral move, at home or internationally.
- Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
- Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks' gender-neutral parental leave.
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law
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