We are an innovative global healthcare company that helps the world stay ahead of infectious diseases by delivering more than 500 million vaccine doses a year. Across different countries, our talented teams are exploring new technologies to protect people and promote healthy communities. We chase the miracles of science every single day, pursuing progress to make a real impact on millions of patients around the world.
*At this time, Sanofi will not sponsor a new applicant for employment authorization, or offer any immigration related support for this position (i.e. H1B, F-1 OPT, F-1 STEM OPT, F-1 CPT, J-1, TN, or another type of work authorization). **
Essential Duties and Responsibilities:
The candidate is expected to learn how to use structural biology tools such cryo-EM and/or X-ray crystallography to elucidate antigen-antibody complex structures
The candidate is expected to prepare negative staining EM samples and perform data collection and data analysis using cryoSparc or equivalent
The candidate will participate in the cryo-EM sample preparation & optimization, grid screening and data collection using cryogenic electron microscope (Glacios and Krios)
The candidate will perform cryo-EM data processing using cryoSparc or equivalent and model building using Phenix, Coot and Isolde
The work involves the interpretation of biochemical results of antigen-antibody complexes (ELISA, SPR, BLI etc)
The work also involves the data analysis for protein quality (SEC, DSF, DSC etc)
The candidate is expected to generate in-silico structural model using Alphafold or other protein modeling algorithms
The candidate is expected to have a solution-focused, team-oriented mindset and will interact closely with other investigators in research and development of novel vaccine candidates
This is a hands-on, laboratory-based role in a highly collaborative research environment
Role will require planning, designing, executing, interpreting, and presenting data in an effective and scientific manner
Participate in scientific discussions focusing on current technology of structural biology
Maintain detailed records and communicate progress and challenges, as necessary
Perform timely electronic laboratory notebook entries, review and submission for completed experiments.
About you
Basic Qualifications:
Currently pursuing a PhD in Molecular Biology, Biochemistry, Biophysics, Structural Biology, or closely related discipline
Must have permanent US work authorization
Must be able to relocate to our Waltham office location and complete the full duration on the Co-op
A background in structural biology is required
Ability to independently design, plan and execute scientific studies, including operation and maintenance of relevant instruments and troubleshooting are required
Strong interpersonal, communication, collaboration and problem-solving skills are needed
Preferred Qualifications:
Experience with cryo-EM sample preparation and grid clipping is preferred
Experience with cryo-EM data processing and model building is preferred
Deep knowledge and hands on experience with the biochemical and biophysical tools (SPR, BLI, DSF, SEC etc.) is preferred
Advanced skill in structural viewing program such as Pymol and ChimeraX is preferred
Familiarity with viral fusion protein and antibody biology is preferred
Why Choose Us?
Bring the miracles of science to life alongside a supportive, future-focused team.
Discover endless opportunities to grow your talent and drive your career, whether it's through a promotion or lateral move, at home or internationally.
Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks' gender-neutral parental leave.
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
