Department:

Lineberger Compr Cancer Center - 426801

11/15/2024

Yes

Postdoctoral Scholar

Post-Doc Research Associate

PDS004385

Full-Time Temporary

40

1

Chapel Hill, NC

North Carolina, US

Dependent on Qualifications/Experience

02/01/2025

12 Months

A global higher education leader in innovative teaching, research and public service, the
University of North Carolina at Chapel Hill consistently ranks as
one of the nation's top public universities and is among is the top ten research universities in the nation for federal research expenditures as well as for federally funded social and behavioral sciences research and development.Here at Carolina, our highly skilled postdocs play a vital role in our research enterprise and towards our overall commitment to research excellence. Across many disciplines, postdocs contribute to the intellectual vitality of the University. They provide innovative ideas and perspectives, foster a stimulating research environment and advance knowledge within their fields. Postdocs are crucial members of our scientific research workforce, contributors to our research outputs and an important reason why Carolina is one of the leading public research institutions in the country.UNC-Chapel Hill offers postdocs comprehensive
medical and vision coverage, paid leave, and
benefits and services that support professional development and a healthy work/life balance. Chapel Hill regularly ranks as one of the best college towns and best places to live in the United States, a reputation guided by the diverse social, cultural, recreation and professional opportunities that span the campus and community.

The UNC School of Medicine has a rich tradition of excellence and care. Our mission is to improve the health and wellbeing of North Carolinians, and others whom we serve. We accomplish this by providing leadership and excellence in the interrelated areas of patient care, education, and research. We strive to promote faculty, staff, and learner development in a diverse, respectful environment where our colleagues demonstrate professionalism, enhance learning, and create personal and professional sustainability. We optimize our partnership with the UNC Health System through close collaboration and commitment to service.
OUR VISION
Our vision is to be the nation's leading public school of medicine. We are ranked 2nd in primary care education among all US schools of medicine and 5th among public peers in NIH research funding. Our Allied Health Department is home to five top-ranked divisions, and we are home to 18 top-ranked clinical and basic science departments in NIH research funding.
OUR MISSION
Our mission is to improve the health and well-being of North Carolinians and others whom we serve. We accomplish this by providing leadership and excellence in the interrelated areas of patient care, education, and research.
Patient Care: We will promote health and provide superb clinical care while maintaining our strong tradition of reaching underserved populations and reducing health disparities across North Carolina and beyond.
Education: We will prepare tomorrow's health care professionals and biomedical researchers by facilitating learning within innovative curricula and team-oriented interprofessional education. We will cultivate outstanding teaching and research faculty, and we will recruit outstanding students and trainees from highly diverse backgrounds to create a socially responsible, highly skilled workforce.
Research: We will develop and support a rich array of outstanding health sciences research programs, centers, and resources. We will provide infrastructure and opportunities for collaboration among disciplines throughout and beyond our University to support outstanding research. We will foster programs in the areas of basic, translational, mechanistic, and population research.

This Postdoctoral Research Associate would support studies to examine a role for the tumor-intrinsic NLRP3 inflammasome in immune evasion associated with the process of tumor dormancy and treatment resistance persistor cell development, tumor relapse, and metastatic progression. This work would involve a combination of ex vivo tumor-T cell co-culture assays, the use of in vivo tumor models, and the utilization of tumor clinical specimens. Techniques would include the use of CRISPR/Cas9-targeted gene deletion, microbead and FACS cell purification, flow cytometry analysis, Western blot, qrt-PCR, ELISA, RNAseq, scRNAseq, micro-CT imaging, IHC, FISH, and proximity ligation assays. Additional work involving performing and analyzing spatial transcriptomics may also be involved.

PhD required.

The competitive candidate will have experience conducting mouse tumor model studies, tissue culture studies, and familiarity with the use of flow cytometry and immunohistochemistry.

Prior experience in conducting and analyzing RNAseq transcriptional analysis and the use of CRISPR/Cas9 is preferred.

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