Job ID: 2024-16974 Type: Research # of Openings: 1 Category: 1199 Union Albert Einstein College of Medicine
Overview
The Institute for Brain Disorders and Neural Regeneration of the Albert Einstein College of Medicine and the Laboratory of Stem Cell Biology and Epigenomic and Regenerative Medicine of Dr. Mark F. Mehler is seeking a Research Technician C depending on qualifications. Our laboratory group has a special interest in the developmental pathogenesis of neurodegenerative diseases, with a focus on Huntington’s disease (HD), and the novel early molecular, cellular, and systems-level impairments that predispose to degenerative dementia during later life with a focus on cutting edge therapeutic initiatives to identify previously unanticipated epigenetic and regenerative target processes that may be more effective when employed during the pre-manifest stage of disease.
Responsibilities
Selected applicants will be expected to:
Perform animal husbandry, including ear ID tagging, tissue processing for genotyping, mating schedules, colony surveillance, including IACUC mandated monthly screenings based on Body Conditioning Scoring Tests, mice separation and tracking, data input and maintenance of mouse colony software, euthanasia of surplus or sick mice. These activities include initial setting up of animal colonies, generation of mouse breeders, and colony expansion.
Compliance with IACUC Environmental and Biohazard policies, handling and tracking of biospecimens between Einstein Core Facilities, database maintenance, reagent ordering and re-stocking, mouse orders, buffer preparation and re-stocking and collaborative support to other research staff involved in this grant.
Perform tissue processing, immunofluorescence microscopy and ultrastructural analysis, stereological examination.
Assist in performing neurobehavioral testing procedures.
Assist in allograft preparation for transplantation analyses, optogenetic protocols, molecular techniques including single cell RNA-seq, histone occupancy, ChIP-seq, spatial transcriptomics, examination for the molecular architecture of trinucleotide repeat expansion and SNPs of targeted DNA repair genes.
Assist in protocols for generation of IPSCs and use of neural organoid techniques.
The person will:
Perform a moderate number of simple or moderate technical procedures;
Require only infrequent guidance;
Frequently be responsible for ordering supplies;
Occasionally be responsible for requesting quotes and information for purchasing equipment for the laboratory;
Occasionally modify technical procedures;
Occasionally train or guide other lab members;
May occasionally operate, maintain and troubleshoot complex, high tech equipment;*
May modify experimental protocols;
Occasionally analyze and interpret data;
May occasionally make written contributions to papers and grant proposals;*
An understanding of moderately complex scientific literature and moderate understanding of research goals and rationale is required.
*May not be applicable.
Qualifications
Required to have at least a Bachelor's Degree in a related science or equivalent skills or experience, and two to four and one half years of related experience.
Strong scientific training background, knowledge of biostatistical programs and excellent writing skills preferred.
