Job Description:

Senior Research Investigator - Discovery Research





University Overview



The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn's distinctive interdisciplinary approach to scholarship and learning.


Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.


The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.




Posted Job Title

Senior Research Investigator - Discovery Research




Job Profile Title

Research Investigator, Senior




Job Description Summary

The Gene Therapy Program (GTP) is entering a new era of unprecedented opportunity with the great potential to reshape the face of medicine as we know it. Our discoveries have set the stage for successful treatments and possibly even cures for devastating genetic diseases.


The laboratory of Dr. Jim Wilson, at GTP of the University of Pennsylvania, has been a leader in the development of innovative vector technology for close to three decades. We have emerged as the “go-to” organization for public and private partners, who want to participate in the gene therapy space. Currently, we are positioned to lead another round of vector innovation and establish pre-clinical and clinical proof-of-concept in therapeutic applications of in-vivo genome editing.


Continuation of all GTP positions is contingent upon funding.




Job Description



Due to the continued growth of our program, we are searching for a new Senior Research Investigator (SRI) to continue work in the areas of next-generation AAV vector design.


As an SRI, you will be involved in the development of next-generation AAV vectors that will revolutionize the field of gene therapy. In collaboration with your Research Director, you will execute on designed work plans. You may take the lead some related projects. In each case, you will be working in the setting of large interdisciplinary teams, where you will function independently in the execution of in vitro and in vivo experiments while working cross-functionally with core labs and resources. With oversight of the Research Director, you will perform design, optimize, and implement complex experiments within specified timelines. You will work closely with the research director to assure that the research program adheres to the work plan and stays within budget. Also, you will have the opportunity to present research externally and you may contribute to writing/reviewing manuscripts, protocols, and SOPs.


Qualified candidates will have expertise with in vitro and in vivo experiments as well as a background in protein engineering, virology, and molecular biology.


Joining GTP offers scientific professionals the unique opportunity of seeing their research go from bench to bedside and discoveries that could one day lead to cures.



Top Candidates will possess:

• Ph. D. / MD / DVM degree in the field of molecular biology, biochemistry, enzymology, virology, protein engineering, or related field and a minimum of 5 years of relevant research experience required.


• Experience working in industry preferred, but not required.


• The successful candidate must thrive in a team environment, have excellent written and oral communication skills, ability to prioritize in a fast-paced environment, and proficiency with standard methods of data analysis.

This posting describes the responsibilities and requirements for a Senior Research Investigator role. If you meet the qualifications outlined and have an interest in being considered for new positions that become available, please apply to this posting. Your information will be reviewed and you will be contacted directly if we would like to learn more about your background, in consideration for the current and/or future openings.





Job Location - City, State

Philadelphia, Pennsylvania




Department / School

Perelman School of Medicine




Pay Range





Affirmative Action Statement

Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.




Special Requirements

Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.





To apply, visit https://wd1.myworkdaysite.com/en-US/recruiting/upenn/careers-at-penn/job/Translational-Research-Laboratories/Senior-Research-Investigator---Discovery-Research_JR00019625

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