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Job Description:
Summary:
The Research Assistant is responsible for assisting with conducting cell biology and molecular biology studies on human normal and cancer cell models. Responsibilities will be to develop genetically modified cell lines via gene editing or gene expression, to maintain cell line stocks and the lab cell line database. Under the supervision of the Principal Investigator, the Research Assistant will assist with maintaining human normal and cancer cell cultures, evaluating DNA damage in response to chemotherapy and environmental genotoxins as well as validating the imposed genetic change in the cell line models. The Research Assistant will also be responsible for keeping supplies in stock and will provide technical support for research projects in general.
Research in Dr. Sobol's lab focuses on mechanisms of DNA repair, PARP and NAD+ metabolism in human cells and the convergent role of these pathways in response to environmental genotoxins and chemotherapy. A major goal in the lab is to use biochemical, genetic, and imaging modalities to use proteomic and genetic modalities to study DNA repair protein complexes that respond to DNA damage induced by environmental genotoxins and chemotherapy and how this pathway affects the regulation of cellular metabolism via ADP-ribosylation signaling and alterations in NAD+ metabolism. Recent efforts have focused on the role of DNA repair pathways and the regulation of PARP1/PARP2 activation in response to replication stress, identification of novel targets to overcome PARP-inhibitor resistance and the development of novel biological tools and assays to evaluate genotoxic stress and PARP-activation that may be used for the discovery of novel compounds that may be used in the treatment of cancer and evaluating genotoxin response.
This is a fixed term position with a current end date of one year from hire, which may be extended based upon available funding.
Job Qualifications:
Education and Experience:
Required: Bachelor's degree in biology-related field.
Required: Prior related experience or extensive coursework. (grade 7)
Required: 1-2 years of experience in a research lab. (grade 8)
Undergraduate research experience in molecular biology, proteomics, or cancer biology is highly desired.
General background knowledge of cancer biology is a plus
And/or equivalent combination of education and experience.
Job Competencies:
Interest in scientific research
Ability to be organized and productive
Ability to keep accurate records
Ability to follow detailed instructions
Proficiency with computers and essential software programs (such as MS office)
Excellent verbal and written communications skills and be able to present complex data in clear presentations.
The person in this position frequently communicates to faculty and staff who inquire about their research. Must be able to exchange accurate information.
Ability to work independently as well as collaboratively with a diverse group of people, with vastly different skills and training.
Occasionally requires weekend hours for experimental monitoring
Possesses a willingness and ability to support a diverse and inclusive campus community
CRIMINAL BACKGROUND AND EDUCATION CHECK REQUIRED
Note: This position is not eligible for Visa sponsorship from Brown University.
Benefits of Working at Brown:
Information on the Benefits of Working at Brown can be found here.
Recruiting Start Date:
2024-10-07
Job Posting Title:
Research Assistant
Department:
Department of Pathology and Laboratory Medicine
Grade:
Grade 7
Worker Type:
Employee
Worker Sub-Type:
Fixed Term (Fixed Term)
Time Type:
Full time
Scheduled Weekly Hours:
37.5
Position Work Location:
Onsite
Submission Guidelines:
Please note that in order to be considered an applicant for any staff position at Brown University you must submit an application form for each position for which you believe you are qualified. Applications are not kept on file for future positions. Please include a cover letter and resume with each position application.
As an EEO/AA employer, Brown University provides equal opportunity and prohibits discrimination, harassment and retaliation based upon a person's race, color, religion, sex, age, national or ethnic origin, disability, veteran status, sexual orientation, gender identity, gender expression, or any other characteristic protected under applicable law, and caste, which is protected by our University policies.
